Table 4.
Multivariate adjusted rate ratios by descriptive characteristics for individuals with 300 or more cell equivalents scoreda.
| Descriptive characteristics | Number of subjects (N = 1400) | Average number of cell equivalents | Number of translocations | Rate ratio | 95% CI | |
|---|---|---|---|---|---|---|
| Age | 0 | 294 | 985 | 103 | 0.06 | (0.04 0.09) |
| 1~4 | 2 | 373 | 2 | 0.27 | (0.03 2.36) | |
| 5~9 | 7 | 424 | 3 | 0.11 | (0.02 0.66) | |
| 10~14 | 20 | 1229 | 75 | 0.47 | (0.31 0.70) | |
| 15~19 | 60 | 854 | 99 | 0.35 | (0.24 0.49) | |
| 20~24 | 148 | 834 | 265 | 0.37 | (0.29 0.48) | |
| 25~29 | 119 | 816 | 361 | 0.64 | (0.52 0.80) | |
| 30~34 | 81 | 815 | 229 | 0.57 | (0.45 0.74) | |
| 35~39 | 106 | 761 | 375 | 0.77 | (0.62 0.96) | |
| 40~44 | 93 | 730 | 425 | 1.00 | (referent) | |
| 45~49 | 99 | 694 | 533 | 1.27 | (1.05 1.55) | |
| 50~54 | 96 | 745 | 542 | 1.25 | (1.03 1.52) | |
| 55~59 | 86 | 686 | 501 | 1.37 | (1.12 1.67) | |
| 60~64 | 61 | 726 | 488 | 1.78 | (1.45 2.18) | |
| 65~69 | 53 | 578 | 300 | 1.60 | (1.27 2.03) | |
| 70~74 | 48 | 650 | 446 | 2.29 | (1.85 2.82) | |
| 75~79 | 15 | 651 | 154 | 2.52 | (1.91 3.35) | |
| 80+ | 12 | 435 | 72 | 2.03 | (1.38 3.00) | |
| Gender | Male | 811 | 737 | 3298 | 1.00 | (referent) |
| Female | 589 | 895 | 1675 | 0.92 | (0.83 1.03) | |
| Smoking | Nonsmokers | 804 | 813 | 2610 | 1.00 | (referent) |
| Smokers | 596 | 791 | 2363 | 1.19 | (1.09 1.30) | |
| Race | White | 1064 | 730 | 4061 | 1.00 | (referent) |
| Asian | 41 | 1027 | 452 | 1.23 | (0.63 2.38) | |
| Black | 256 | 1445 | 392 | 0.84 | (0.71 0.99) | |
| Others | 39 | 673 | 68 | 1.06 | (0.72 1.57) | |
| Laboratory regionb | North America | 856 | 908 | 2438 | 1.00 | (referent) |
| Asia | 31 | 1578 | 371 | 0.86 | (0.43 1.72) | |
| Central and Eastern Europe | 29 | 476 | 86 | 1.75 | (1.24 2.47) | |
| Western Europe | 484 | 589 | 2078 | 0.99 | (0.89 1.09) | |
To calculate the absolute expected translocation rate for a given combination of values of the covariates shown, multiply the estimated model intercept, i.e., 0.59, by the relative effects shown in the table, e.g., for a 62-year old Black male smoker who was evaluated in a North American laboratory, the expected translocation rate is calculated as 0.59 × 1.78 × 1.00 × 1.19 × 0.84 × 1.00=1.04 translocations per 100 cells. The equation does not account for any effect modification by cigarette smoking or race.
Asia: NIRS and NIRP, RERF, SNU; Central and Eastern Europe: CRIRR, LGE; North America: Health and Welfare Canada, LLNL, ORAU; Western Europe: BfS, GSF, HPA, IRSN, LUMC, STUK, UAB, WRI