Figure 2. Pharmacodynamics of oxime administration.

Time course of plasma pralidoxime concentration in patients allocated to receive pralidoxime chloride 2 g loading dose over 20 min followed by 0.5 mg/h until 7 d or until atropine no longer required (blue line, mean±SD; n≤85). A predicted time course (green line) was calculated for a 50 kg person using the kinetic data of Sidell and colleagues [42].