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. 2009 Jun 30;6(6):e1000104. doi: 10.1371/journal.pmed.1000104

Table 5. Published RCTs of pralidoxime with more than 20 patients showing doses of the pralidoxime cation administered in each arm.

Trial Salta Pralidoxime Cation per Gram of Salt Arm 1 Cation Dose Arm 2 Cation Dose
Vellore [35] Chlorideb 0.795 g 0.80 g loading dose over 1–5 min No loading dose, then infusion of 4.8 g over 1st 24 h, 2.4 g over 2nd 24 h, 1.6 g over 3rd 24 h, and 0.8 g over 4th 24 h
Vellore [36] Chlorideb 0.795 g None No loading dose, then infusion of 9.5 g over 3 dc
Baramati [29] Iodide 0.520 g 1.04 g loading dose over 30 min, then 0.52 infused over 1 hr every 4 h 1.04 g loading dose over 30 min, then 0.52 g/h constant infusion for 48 h, then 0.52 g infused over 1 h every 4 h
This trial Chloride 0.795 g None 1.6 g loading dose over 20 min, then 0.4 g/h constant infusion for up to 7 d
a

The different salts contain different quantities of pralidoxime [37],[43].

b

Not stated in papers. Personal communication, Dr. J. V. Peter.

c

Exact dosage regimen over the 3 d not stated in paper.