Table 5. Published RCTs of pralidoxime with more than 20 patients showing doses of the pralidoxime cation administered in each arm.
Trial | Salta | Pralidoxime Cation per Gram of Salt | Arm 1 Cation Dose | Arm 2 Cation Dose |
Vellore [35] | Chlorideb | 0.795 g | 0.80 g loading dose over 1–5 min | No loading dose, then infusion of 4.8 g over 1st 24 h, 2.4 g over 2nd 24 h, 1.6 g over 3rd 24 h, and 0.8 g over 4th 24 h |
Vellore [36] | Chlorideb | 0.795 g | None | No loading dose, then infusion of 9.5 g over 3 dc |
Baramati [29] | Iodide | 0.520 g | 1.04 g loading dose over 30 min, then 0.52 infused over 1 hr every 4 h | 1.04 g loading dose over 30 min, then 0.52 g/h constant infusion for 48 h, then 0.52 g infused over 1 h every 4 h |
This trial | Chloride | 0.795 g | None | 1.6 g loading dose over 20 min, then 0.4 g/h constant infusion for up to 7 d |