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Arteriolar vascular smooth muscle NO sensitivity is not altered after particle inhalation. SNP was locally applied to individual arterioles via microiontophoresis and produced equivalent dose-dependent dilations in all groups that were near maximal (vs. ADO). Sham-Control, n = 7; 67 μg fine TiO2; n = 9, and 10 μg nano-TiO2, n = 10. *p < 0.05 versus 0 nAmp for all groups. †p < 0.05 versus 5 nAmp for all groups. ‡p < 0.05 versus 10 nAmp for all groups. Values are means ± SE.
