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. 2009 Apr 30;110(1):47–60. doi: 10.1093/toxsci/kfp094

FIG. 4.

FIG. 4.

Serum and liver unconjugated bile acids in control and ANIT-treated wild-type, FXR-null, and PXR-null mice. Bile acids were quantified by UPLC-MS/MS as described in the “Materials and Methods” section. (A) Serum unconjugated bile acids are expressed as μg/ml ± SEM. (B) Liver unconjugated bile acids are expressed as μg/g ± SEM. “*” Represents significant differences (p < 0.05) compared to control mice (n = 5 animals). “#” Represents significant differences (p < 0.05) compared with ANIT-treated wild-type mice.