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. Author manuscript; available in PMC: 2009 Jun 15.
Published in final edited form as: Pharmacol Rev. 2008 Dec 12;60(4):470–512. doi: 10.1124/pr.108.000604

FIG. 1.

FIG. 1

Schematic representation of incretin secretion and action. GIP and GLP-1 are secreted after food ingestion, and they then stimulate glucose-dependent insulin secretion. Once released, GIP and GLP-1 are subject to degradation by DPP4 on lymphocytes and on endothelial cells of blood vessels. The red cells in the islets are insulin-containing (β) cells and the green cells are glucagon-containing (α) cells.