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. Author manuscript; available in PMC: 2009 Jun 15.
Published in final edited form as: Ann Neurol. 2009 Apr;65(4):403–413. doi: 10.1002/ana.21610

Table 3.

Cerebrospinal Fluid Biomarker Concentrations and Ratios in Non–Alzheimer’s Disease Neuroimaging Initiative Samples Collected before Autopsy for Alzheimer’s Disease and an Age-Matched Elderly Cognitively Normal Control Group

Characteristics tau (pg/ml) Aβ1–42 (pg/ml) p-tau181p(pg/ml) tau/Aβ1–42 Ratio p-tau181P/Aβ1–42 Ratio
AD (n = 56)
 Median 122 129 29 1.0 0.2
 Mean ± SD 135 ± 95 132 ± 34 39 ±29 1.1 ± 1.0 0.3 ± 0.2
 95% CI 110–161 123–141 31–47 0.9–1.4 0.2–0.4
NC (n = 52)
 Median 52 245 13 0.2 0.06
 Mean ± SD 57 ± 30 233 ± 58 18 ±16 0.3 ± 2 0.1 ± 0.1
 95% CI 49–65 217–250 14–23 0.2–0.4 0.06–0.1

Mann–Whitney test: p < 0.0001 for each biomarker or ratio for Alzheimer’s disease (AD) vs cognitively normal (NC). Aβ1–42 =amyloid-β 1 to 42 peptide; p-tau181p = tau phosphorylated at the threonine 181 position; SD = standard deviation; CI = confidence interval.