Table 2.

Similarities between rpFPI-induced PTE in the rat and human PTE.

1.The traumatic brain injury model is mechanically very similar to human cases of closed head injury.

2.Chronic spontaneous recurrent seizures appear after a single event of traumatic brain injury.

3.Seizure free “latent period” between the initiating injury and the onset of the epileptic condition.

4.Seizures are focal, with or without secondary bilateral spread.

5.The ictal behavior is consistent with human complex partial seizures.

6.Neocortical and hippocampal epileptic foci (dual pathology).

7.Preferential recruitment of hippocampus by frontal-parietal foci, but not vice versa.

8.Progressive temporal lobe sclerosis in a subgroup of epileptic individuals, and not in others.

9.Time-dependent changes in epileptic syndrome.

10.Cases of remission.