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. Author manuscript; available in PMC: 2009 Jul 11.
Published in final edited form as: Biochem Biophys Res Commun. 2008 Mar 31;371(4):906–911. doi: 10.1016/j.bbrc.2008.03.113

Figure 3. Diagram Showing How Signaling Amplitudes or Synergism can Affect Gene Induction.

Figure 3

(A) Schematic of how the amplitude in a signal can give rise to distinct gene expression profiles. Specifically at high signal amplitude, signaling molecules with a low affinity for say Ca2+, can become activated and result in a distinct genetic output. (B) Schematic of how two signal transduction pathways can coordinate to lead to the expression of select genes, with one pathway mediating chromatin modification (for example, p38) and the other pathway initiating transcription (for example, p65).