Table 1. Analysis of Gene Sub-Clusters Reveals Affected Pathways and Multiple Oscillatory Components in the TNF Signaling Cascade.

Primary macrophages were prepared as in Legend to Figure 1 and subject to microarray analysis. Early and late oscillator genes are defined in the proceeding paper. KEGG Pathway Analysis was used to derive z-scores, and statistically significant oscillators with a z-score >2 were identified.

KEGG Pathway	Z-score	Oscillatory components
Small cell lung cancer
Early Oscillators	4.04	IκB α, TRAF1, Prostaglandin-endoperoxide synthase 2, FAK1
Late Oscillators	3.47	NF-κB p100, p15, INK4b, IAP
T cell receptor signaling
Early Oscillators	3.82	IκBα, RasGRP1, TNF, and MALT1
Late Oscillators	1.14	NF-κ p100
Adipocytokine signaling
Early Oscillators	3.27	IκBα, IL-1, and TNF
Late Oscillators	1.57	NF-κ p100, and FACS (acetyl-CoA synthetase)
Apoptosis
Early Oscillators	2.93	IκBα, and TNF
Late Oscillators	2.47	NF-κ p100, IAP, and Fas
TGF-beta signaling
Early Oscillators	2.93	Smurf1, ID3, and TNF
Late Oscillators	0.21	p15 INK48
Diabetes Pathways
Early Oscillators	2.65–2.77	SOCS3, IL-1, and TNF
Late Oscillators	2.25–3/52	Fas, MHCII, HNF6, and Nr5a2