Table 3.
Relation of Plasma Lipids and the Risk of Prevalent AD
| No. (%) of Subjects* | ||||||
|---|---|---|---|---|---|---|
| Lipid, Quartile (Range, mg/dL) |
AD (n = 244) |
Control Subjects (n = 2226) |
B (SE) | P Value | OR (95% CI)† | OR (95% CI)‡ |
| Total cholesterol | ||||||
| 1 (≤172.00) | 72 (29.5) | 552 (24.8) | 1.00 | 1.00 | ||
| 2 (172.01–197.00) | 63 (25.8) | 565 (25.4) | 0.06 (0.20) | .76 | 1.06 (0.72–1.58) | 0.96 (0.61–1.53) |
| 3 (197.01–225.00) | 56 (23.0) | 552 (24.8) | −0.19 (0.21) | .36 | 0.82 (0.55–1.24) | 0.72 (0.44–1.16) |
| 4 (≥225.01) | 53 (21.7) | 557 (25.0) | −0.12 (0.21) | .56 | 0.89 (0.59–1.35) | 0.94 (0.58–1.52) |
| Trend test | P = .37 | P = .52 | ||||
| Non–HDL-C | ||||||
| 1 (≤124.00) | 71 (29.1) | 562 (25.2) | 1.00 | 1.00 | ||
| 2 (124.01–149.00) | 65 (26.6) | 555 (24.9) | 0.12 (0.20) | .54 | 1.13 (0.77–1.66) | 1.15 (0.73–1.81) |
| 3 (149.01–176.00) | 54 (22.1) | 575 (25.8) | −0.12 (0.20) | .57 | 0.89 (0.60–1.33) | 0.88 (0.55–1.41) |
| 4 (≥176.01) | 54 (22.1) | 534 (24.0) | 0.01 (0.21) | .98 | 1.01 (0.67–1.51) | 1.05 (0.65–1.68) |
| Trend test | P = .74 | P = .86 | ||||
| HDL-C | ||||||
| 1 (≤37.00) | 69 (29.2) | 494 (23.4) | 1.00 | 1.00 | ||
| 2 (37.01–45.00) | 46 (19.5) | 555 (26.3) | −0.66 (0.22) | .003 | 0.52 (0.34–0.80) | 0.47 (0.28–0.78) |
| 3 (45.01–55.00) | 51 (21.6) | 513 (24.3) | −0.50 (0.22) | .03 | 0.61 (0.39–0.94) | 0.58 (0.35–0.97) |
| 4 (≥55.01) | 70 (29.7) | 552 (26.1) | −0.30 (0.21) | .16 | 0.74 (0.49–1.13) | 0.66 (0.41–1.08) |
| Trend test | P = .34 | P = .22 | ||||
| Triglycerides | ||||||
| 1 (≤97.00) | 73 (29.9) | 548 (24.8) | 1.00 | 1.00 | ||
| 2 (97.01–135.00) | 65 (26.6) | 536 (24.3) | −0.16 (0.20) | .43 | 0.85 (0.57–1.27) | 0.93 (0.58–1.50) |
| 3 (135.01–191.00) | 50 (20.5) | 578 (26.2) | −0.42 (0.22) | .05 | 0.65 (0.43–1.00) | 0.80 (0.48–1.32) |
| 4 (≥191.01) | 53 (21.7) | 545 (24.7) | −0.19 (0.22) | .37 | 0.82 (0.54–1.26) | 0.95 (0.58–1.56) |
| Trend test | P = .21 | P = .72 | ||||
| LDL-C | ||||||
| 1 (≤96.50) | 69 (28.3) | 550 (24.7) | 1.00 | 1.00 | ||
| 2 (96.51–118.80) | 59 (24.2) | 559 (25.1) | 0.10 (0.21) | .63 | 1.10 (0.74–1.66) | 0.87 (0.54–1.40) |
| 3 (118.81–142.80) | 57 (23.4) | 565 (25.4) | −0.10 (0.21) | .65 | 0.91 (0.60–1.37) | 0.84 (0.52–1.36) |
| 4 (≥142.81) | 59 (24.2) | 552 (24.8) | −0.02 (0.21) | .94 | 1.02 (0.68–1.53) | 1.02 (0.63–1.65) |
| Trend test | P = .83 | P = .99 | ||||
Abbreviations: AD, Alzheimer disease; B, estimated logistic regression coefficient; CI, confidence interval; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; OR, odds ratio.
SI conversion factors: To convert cholesterol to millimoles per liter, multiply by 0.0259; triglycerides to millimoles per liter, multiply by 0.0113.
*
Some percentages are based on an incomplete sample owing to small amounts of missing data. Percentages have been rounded and may not total 100.
†
Adjusted for sex, age, education, and race.
‡
Adjusted for body mass index, apolipoprotein E genotype, diabetes, heart disease, and hypertension.