Table 7.
Relation of Plasma Lipids and the Risk of Incident AD*
| No. (%) of Subjects | HR (95% CI) | |||
|---|---|---|---|---|
| Lipid, Quartile | ||||
| (Range, mg/dL) | At-Risk Population | Incident AD | Model 1† | Model 2‡ |
| Total cholesterol | ||||
| 1 (≤176.00) | 293 (25.1) | 43 (14.7) | 1.00 | 1.00 |
| 2 (176.01–202.50) | 291 (24.9) | 26 (8.9) | 0.63 (0.38–1.04) | 0.58 (0.34–0.97) |
| 3 (202.51–229.00) | 293 (25.1) | 29 (9.9) | 0.85 (0.52–1.40) | 0.82 (0.48–1.41) |
| 4 (≥229.01) | 291 (24.9) | 21 (7.2) | 0.55 (0.32–0.95) | 0.48 (0.26–0.86) |
| Trend test | P = .07 | P = .04 | ||
| Non–HDL-C | ||||
| 1 (≤128.00) | 299 (25.6) | 41 (13.7) | 1.00 | 1.00 |
| 2 (128.01–154.00) | 285 (24.4) | 28 (9.8) | 0.76 (0.48–1.22) | 0.79 (0.48–1.29) |
| 3 (154.01–182.00) | 296 (25.4) | 31 (10.5) | 0.84 (0.53–1.37) | 0.88 (0.54–1.43) |
| 4 (≥182.01) | 285 (24.4) | 19 (6.7) | 0.61 (0.36–1.04) | 0.60 (0.34–1.04) |
| Trend test | P = .11 | P = .11 | ||
| HDL-C | ||||
| 1 (≤36.00) | 266 (24.1) | 29 (10.9) | 1.00 | 1.00 |
| 2 (36.01–45.00) | 309 (27.9) | 27 (8.7) | 0.87 (0.51–1.51) | 0.79 (0.44–1.42) |
| 3 (45.01–55.00) | 260 (23.5) | 31 (11.9) | 0.85 (0.49–1.46) | 0.97 (0.54–1.75) |
| 4 (≥55.01) | 271 (24.5) | 27 (10.0) | 0.72 (0.41–1.26) | 0.70 (0.37–1.32) |
| Trend test | P = .27 | P = .39 | ||
| Triglycerides | ||||
| 1 (≤121.00) | 295 (25.5) | 37 (12.5) | 1.00 | 1.00 |
| 2 (121.01–161.00) | 283 (24.5) | 29 (10.2) | 0.82 (0.50–1.35) | 0.75 (0.44–1.27) |
| 3 (161.01–224.00) | 288 (24.9) | 29 (10.1) | 0.98 (0.58–1.63) | 0.89 (0.51–1.56) |
| 4 (≥224.01) | 290 (25.1) | 23 (7.9) | 0.76 (0.44–1.34) | 0.76 (0.42–1.39) |
| Trend test | P = .48 | P = .50 | ||
| LDL-C | ||||
| 1 (≤94.35) | 290 (24.9) | 36 (12.4) | 1.00 | 1.00 |
| 2 (94.36–117.30) | 291 (25.0) | 32 (11.0) | 1.00 (0.62–1.63) | 0.99 (0.59–1.65) |
| 3 (117.31–142.75) | 291 (25.0) | 26 (8.9) | 0.78 (0.46–1.31) | 0.78 (0.46–1.34) |
| 4 (≥142.76) | 291 (25.0) | 24 (8.2) | 0.88 (0.51–1.51) | 0.80 (0.46–1.40) |
| Trend test | P = .43 | P = .31 | ||
Abbreviations: AD, Alzheimer disease; CI, confidence interval; HDL-C, high-density lipoprotein cholesterol; HR, hazard ratio; LDL-C, low-density lipoprotein cholesterol.
SI conversion factors: To convert cholesterol to millimoles per liter, multiply by 0.0259; triglycerides to millimoles per liter, multiply by 0.0113.
*
Calculated as Cox proportional hazards model, with age at onset as time variable, as described in the text. Some percentages are based on an incomplete sample due to small amounts of missing data.
†
Adjusted for sex, age, education, and race.
‡
Adjusted for body mass index, apolipoprotein E genotype, diabetes, heart disease, and hypertension.