Table 2.
GO functional annotations for the ten most significant subnetworks (Prostate Cancer Metastasis data).
| Sub-networks | GO annotation | P-value (GO) |
| ACVR1 SMAD5 SMAD4 TFE3 DACH1 SPTBN1 JUN BMP2 SKIL MGP | BMP signaling pathway | 0 |
| ACVR1B TGFB3 TGFB1 BGN ITGAV ACVR2A BMP7 | epithelial to mesenchymal transition | 0 |
| ACVR2A BMP6 SMAD5 SMAD4 ACVR1 ACVR1B TGFB1 | BMP signaling pathway | 0 |
| AKT2 PIK3R1 MME NRAS PIP5K2A TUBG1 NFKB1 TRIP4 PIK3C2B VAV2 CEBPB PIK4CA EGR1 | phosphoinositide phosphorylation | 0 |
| ARF1 TMED2 TMED10 ARFGAP1 AP1G1 AFTIPHILIN PSCD2 | vesicle-mediated transport | 0 |
| BMP2 TGFB1 ITGAV BGN GLI2 LTBP1 TGFB3 BMP7 CSNK1A1 PRKY | epithelial to mesenchymal transition | 0 |
| BMP6 SMAD5 SMAD4 ACVR1 ACVR2A ACVR1B NCOA3 MYC GTF2B PCAF SMAD2 | BMP signaling pathway | 0 |
| BMP7 ACVR1 SMAD5 SMAD4 ACVR2A ACVR1B TGFB1 BMP6 BMP2 TGFB3 | epithelial to mesenchymal transition | 0 |
| CANX MBTPS1 ITGB1 CD46 LGALS3BP ITGAV ITGB1BP1 PXN SERP1 ITGA8 | cell-matrix adhesion | 0 |
| CAV1 PTPRF JUP ITGB4 COL17A1 NID1 LGALS3BP IRS1 FRS2 EDG1 PLEC1 APP TGFB1 CALR APPBP1 | cell adhesion | 0 |
GO terms are enriched for identified sub-networks. P-values are the results of GO term enrichment analyses. The well-known biological processes related to prostate cancer metastasis are denoted by bold-faced letters.