Table 3.

Candidate areas with chromosomal alterations characterizing non-muscle invasive bladder cancers with subsequent progression.

Chromosome	Cytoband	Physical position (hg17/NCBI build 35.1)	chromosomal changes of progressing tumors	Candidate genes (selection)	p (single SNPs)	p (segment)
1	p31.1-p22.3	82–86 Mb	CN gain	BCL10	0.003	n.s.
2	q33.3-q34	208–213 Mb	CN gain	CREB1, MAP2	0.001	0.05
3	p21-p14.3	42–64 Mb	CN gain	CCR-cluster	0.01	n.s.
4	p13	40–45 Mb	CN loss/LOH		0.02	n.s.
6	q15-q23.2	89–133 Mb	CN loss/LOH	TPD52L1	0.01	n.s.
8	p12-p11.21	33 M–43 Mb	CN loss/LOH	SFRP1, TACC1, FGFR1	0.01	n.s.
10	p15.1-p14	3.5 M–13 Mb	CN gain	GATA3, NET1, PKCQ, IL15RA	0.005	n.s.
10	p11	30–36 Mb	CN gain		0.005	n.s.
15	q25.3	84–85 Mb	CN loss		0.01	n.s.

SNP microarray analysis (significance p = probability of detecting difference between progressing and non-progressing tumors by chance, permutation analysis). A survey of the entire genome is possible in Additional Files 2, 3, 4 and 5.