Figure 4.

Correlations between gene expression and DNA methylation. Figure A and B present the plots of the relationships between the gene expression and the methylation of promoters with CGI, promoters without CGI, exons, and introns for MCF-7 and MDA-MB-231 cells, respectively. On the X-axis scale, the degree of methylation for each spot is calculated as the number of tags for a given site divided by the average number of tags for all MluI sites. Similarly, the degree of gene expression on the Y-axis scale is calculated as the expression value for a given gene divided by the average expression value for all genes. Both the methylation and expression values are log-transformed.