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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Inflamm Bowel Dis. 2009 May;15(5):697–706. doi: 10.1002/ibd.20827

FIGURE 1.

FIGURE 1

Carbohydrate structure of L-selectin ligand. Core 1 O-glycans are extended by Core 1 extending β1,3-N-acetylglucosaminyltransferase (Core1-β3GlcNAcT) and sulfated by N-acetylglucosamine-6-O-sulfotransferase 1 (GlcNAc6ST-1) and/or GlcNAc6ST-2 to form 6-sulfo sialyl Lewis X attached to extended core 1 O-glycans. GlcNAc6ST-1 and/or GlcNAc6ST-2 also sulfate GlcNAc residue on core 2 branched O-glycans. 6-sulfo sialyl Lewis X attached to extended core 1 and/or core 2 branched O-glycans functions as an L-selectin ligand. The epitope for the MECA-79 monoclonal antibody (6-sulfo N-acetyllactosamine attached to extended core 1 O-glycans) is shown in dotted box.