Immunohistochemical profile of HEV-like vessels induced in UC. Serial tissue sections obtained from active (upper panels) and remission (lower panels) phases of UC were immunostained for CD34 (as a marker of vascular endothelial cells), MAdCAM-1, and PNAd (MECA-79). A fraction of CD34+ vessels in the colonic lamina propria is also MAdCAM-1-positive, regardless of UC disease activity. In the active phase, MAdCAM-1+ vessels are largely positive for MECA-79. HE = hematoxylin and eosin, Bar = 50 μm.