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. Author manuscript; available in PMC: 2010 May 19.
Published in final edited form as: Acc Chem Res. 2009 May 19;42(5):631–639. doi: 10.1021/ar8002249

Figure 3.

Figure 3

Schematic representation of the initiation PKS module of the R1128 synthase. The cysteine and pantetheinyl thiols of the two KSs and two ACPs, respectively are explicitly shown. Chain growth is initiated by the initiation module, followed by transfer to the elongation module. Those enzymes whose structures are known are shown as ribbon diagrams; their PDB coordinate file-names are: 1MZJ (ZhuH, KSIII), 2NM0 (β-Ketoacyl-Acyl Carrier Protein Reductase, KR); 1TQY (act KS-CLF), 1OR5 (ACP), 1NM2 (MAT). The ACP cartoons in red and blue refer to the ACP from initiation module and elongation module respectively. [KS: Ketosynthase; CLF: Chain Length Factor; ACP: Acyl Carrier Protein; MAT: Malonyl-CoA:ACP Transacylase; KR: Ketoreductase; DH: Dehydratase; ER: Enoyl Reductase; NADP: Nicotinamide Adenine Dinucleotide Phosphate]