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. Author manuscript; available in PMC: 2010 May 19.
Published in final edited form as: Acc Chem Res. 2009 May 19;42(5):631–639. doi: 10.1021/ar8002249

Figure 4.

Figure 4

Aromatic Polyketides produced by (A) act Minimal PKS and (B) R1128 Initiation Module and tcm Minimal PKS. The act minimal PKS synthesizes a C16 carbon chain backbone that is primed by acetyl group. The five and six-carbon primer unit in YT127 and YT127b respectively is derived from the initiation module of the R1128 PKS. In conjunction with this initiation module, the tcm minimal PKS therefore synthesizes an octaketide backbone rather than a decaketide backbone, so that the chain length of the resulting polyketide product remains constant.