Table 2. Patient and tumour characteristics and HIF-1α staining.
|
HIF-1α, number of patients (%)
|
|||
|---|---|---|---|
| Negative | Positive | P-value | |
| Gender | P=0.35 | ||
| Male | 24 (43) | 32 (57) | |
| Female | 18 (53) | 16 (47) | |
| T stage | P=0.48 | ||
| T1/2 | 9 (50) | 9 (50) | |
| T3/4 | 33 (46) | 39 (54) | |
| N stage | P<0.02* | ||
| N0 | 32 (56) | 25 (44) | |
| N1 | 6 (29) | 15 (71) | |
| N2 | 4 (33) | 8 (67) | |
| Differentiation | P=0.58 | ||
| Well | 3 (75) | 1 (25) | |
| Moderate | 33 (45) | 40 (55) | |
| Poor | 6 (46) | 7 (54) | |
| Dukes’ stage | P=0.05 | ||
| Dukes’ A | 9 (53) | 8 (47) | |
| Dukes’ B | 23 (58) | 17 (42) | |
| Dukes C1 | 8 (29) | 20 (71) | |
| Dukes’ C2 | 2 (40) | 3 (60) | |
| Dukes’ stages combined | P<0.02* | ||
| A/B | 32 | 25 | |
| C | 10 | 23 | |
| TNM stage | P<0.05* | ||
| Stage I | 9 (53) | 8 (47) | |
| Stage II | 23 (58) | 17 (42) | |
| Stage III | 10 (30) | 23 (70) | |
| Vascular invasion | P<0.005* | ||
| Absent | 35 (56) | 28 (44) | |
| Intramural | 4 (36) | 7 (64) | |
| Extramural | 3 (19) | 13 (81) | |
| Microvessel density^ | P=0.32 | ||
| <60 vessels | 20 (53) | 18 (47) | |
| ⩾60 vessels | 21 (42) | 29 (58) | |
HIF=hypoxia-inducible factor; TNM=tumour node metastasis.
*Statistically significant at 5% level.