Table 2a. Association between TGFBR1*6A genotypes and risk of colorectal cancer and adenoma.
| Controls n=856a |
All familial cases n=262a
|
Non-HNPCC n=179a
|
HNPCC n=83
|
||||
|---|---|---|---|---|---|---|---|
| Exon 1Genotype | No. of cases (%) | No. of cases (%) | OR (95% CI) | No. of cases (%) | OR (95% CI) | No. of cases (%) | OR (95% CI) |
| 9A/9A | 682 (79.7) | 209 (79.8) | 1.0 | 150 (83.8) | 1.0 | 59 (71.1) | 1.0 |
| 9A/6A | 160 (18.7) | 48 (18.3) | 0.98 (0.68–1.40) | 26 (14.5) | 0.74 (0.47–1.16) | 22 (26.5) | 1.59 (0.95–2.67) |
| 6A/6A | 10 (1.2) | 4 (1.5) | 1.31 (0.41–4.21) | 2 (1.1) | 0.91 (0.20–4.19) | 2 (2.4) | 2.30 (0.50–10.8) |
| 9A/6A and 6A/6A | 170 (19.9) | 52 (19.8) | 1.00 (0.71–1.41) | 28 (15.6) | 0.75 (0.48–1.16) | 24 (28.9) | 1.63 (0.99–2.70) |
| 6A frequency | 0.106 | 0.107 | 0.084 | 0.157 | |||
Abbreviation: HNPCC=hereditary non-polyposis colorectal cancer.
a
Included in the total number are rare TGFBR1 alleles such as *5A, *7A, *8A, *10A, *11A and *12A.