Table 3a. Association between Int7G24A genotypes and risk of colorectal cancer and adenoma.
| Controls n=853 |
All familial cases n=262
|
Non-HNPCC n=179
|
HNPCC n=83
|
||||
|---|---|---|---|---|---|---|---|
| Int7G24A Genotype | No. of cases (%) | No. of cases (%) | OR (95% CI) | No. of cases (%) | OR (95% CI) | No. of cases (%) | OR (95% CI) |
| G/G | 559 (65.5) | 165 (63.0) | 1.0 | 110 (61.4) | 1.0 | 55 (66.3) | 1.0 |
| G/A | 265 (31.1) | 83 (31.7) | 1.06 (0.79–1.44) | 61 (34.1) | 1.17 (0.83–1.65) | 22 (26.5) | 0.84 (0.50–1.41) |
| A/A | 29 (3.4) | 14 (5.3) | 1.64 (0.84–3.17) | 8 (4.5) | 1.40 (0.62–3.15) | 6 (7.2) | 2.10 (0.84–5.29) |
| G/A and A/A | 294 (34.5) | 97 (37.0) | 1.12 (0.84–1.49) | 69 (38.5) | 1.19 (0.86–1.66) | 28 (33.7) | 0.97 (0.60–1.56) |
| A frequency | 0.189 | 0.212 | 0.215 | 0.205 | |||
Abbreviation: HNPCC=hereditary non-polyposis colorectal cancer.