Table 1. Effects of Cipro treatment on toxicity profiles of the 3-day CPT-11 regimen at 150 mg kg⁻¹ per day × 3 days.

Treatment
CPT-11	Cipro	N a	Mortalityb %	Incidence of severe delayed diarrhoea (%)c	Area under curve of the diarrhoea scored	Relative body weight at day 6 (%)e	Tibialis muscle gram per 1000 g body weight at day 9	Medial gastroncnemius muscle gram per 1000 g body weight at day 9
None	None	8	—	—	—	98.5±0.6f	1.80±0.05f	2.05±0.02f
Yes	None	20	45	55.0±3.9	19.5±0.5	80.6±0.7g	1.60±0.03g	1.93±0.04g
Yes	Yes	11	0	47.7±5.5	18.6±0.6	90.5±0.5h	1.74±0.02f	2.04±0.04f

^aN, total animal number of each treatment group.

^bMortality represents percentage of dead rats at the end of the study.

^cIncidence of delayed diarrhoea was calculated for each animal by counting observations of a particular score(s) out of the total eight observations between day 3 and day 7 when diarrhoea developed to its full severity.

^dArea under curve of diarrhoea score was calculated from the diarrhoea score–time graph of each individual animal between day 3 and day 7.

^eRelative body weight at day 6 was calculated by comparing with the body weight at day 0.

^fMeans within a column that do not share a common letter are significantly different (P<0.05).

All data are presented as mean ±s.e.m.

^f,g,hMeans within a column that do not share a common letter are significantly different.