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. 2009 Apr 28;100(10):1581–1588. doi: 10.1038/sj.bjc.6605051

Table 2. Effects of CPT-11 treatment and Cipro on phenotypic distribution of immune cells in MLN and spleen.

  MLN
Spleen
Antibody Healthy controls n=8 CPT-11 alone n=9 CPT-11+Cipro n=6 Healthy controls n=8 CPT-11 alone n=9 CPT-11 + Cipro n=6
B cell+(OX12) (% of total cells) 13.0±0.6a 19.8±1.8b 27.3±1.9c 29.1±0.4a 36.4±1.8b 36.9±1.1b
% OX12+CD45RA− 1.5±0.3a 5.3±0.6b 5.0±1.7b 7.5±0.8a 28.7±3.0b 8.3±0.9a
% OX12+CD45RA+ 98.5±0.3a 94.7±0.6b 95.0±1.7b 92.5±0.8a 71.3±3.0b 91.7±0.9a
% OX12+CD80+ 0.7±0.1a 1.5±0.5a,b 2.6±1.1b 2.8±0.4 3.9±0.7 2.5±0.3
CD3+(% of total cells) 70.8±1.2a 66.4±1.4b 57.5±1.2c 55.4±0.6a 46.4±2.1b 49.6±0.8b
CD3+CD8+(% of total cells) 22.2±0.8a 23.0±0.6a 17.9±0.5b 31.9±0.9a 21.0±0.9b 23.9±1.1b
% CD8+CD71+ 9.2±1.2a 10.5±1.0a 19.3±2.6b 25.6±0.8a 23.9±1.2a 28.8±1.3b
% CD8+CD28+ 4.0±0.6a 50.8±4.5b 75.2±2.9c 10.0±0.5a 52.3±6.3b 44.5±9.3b
% CD8+CD25+ 9.3±0.3a 9.4±1.0a 40.2±9.1b 8.6±0.8a 16.4±3.7b 14.0±1.2b
% CD8+CD62 L+ 38.0±2.0a 42.8±3.1a 30.1±2.4b 33.8±0.9a 34.7±3.1a 15.7±0.6b
% CD8+CD45RA− 62.4±1.7a 76.7±6.5b 38.4±2.5c 31.8±1.2a 45.9±4.6b 28.1±1.5a
% CD8+CD45RA+ 37.6±1.7a 23.3±6.5b 61.6±2.5c 68.2±1.2a 54.1±4.6b 71.9±1.5a
CD3+CD4+(% of total cells) 48.7±0.7a 43.3±1.4b 40.7±1.2b 32.4±0.5a 22.2±1.0b 20.4±1.7b
% CD4+CD71+ 6.5±0.7a 9.2±1.2b 4.4±0.9a 22.1±1.1a 39.9±3.8b 26.7±2.1c
% CD4+CD28+ 5.5±0.3a 73.9±5.1b 85.2±2.2b 15.2±0.9a 60.7±10.4b 77.6±2.5b
% CD4+CD25+ 7.5±0.4a 9.8±0.7b 37.3±11.9c 9.4±0.4a 15.4±2.2b 10.8±0.9a,b
% CD4+CD62L+ 74.7±4.2a 53.3±6.5b 59.4±4.4b 67.8±2.1a 36.1±4.7b 28.4±1.0b
% CD4+CD45RA− 93.8±0.7a 91.9±3.4a 90.6±0.5b 80.2±0.5a 79.9±2.0a,b 83.4±1.3b
% CD4+CD45RA+ 6.2±0.7a 8.1±3.4a,b 9.4±0.5b 19.8±0.5a 20.1±2.0a,b 16.6±1.3b
CD3+CD4+/CD3+CD8+ 2.2±0.1a 1.9±0.0b 2.3±0.1a 1.0±0.0a 1.1±0.0a 0.9±0.1b
CD71 (% of total cells) 15.8±0.7a 12.8±0.9b 14.6±0.6a,b 23.5±0.8a 33.5±2.6b 22.6±2.1a
CD25 (% of total cells) 4.3±0.2a 5.7±0.4b 27.1±7.5c 5.5±0.5a 10.2±1.9b 6.5±0.6a,b
CD28 (% of total cells) 3.4±0.2a 44.8±3.2b 55.4±1.9c 7.4±0.5a 29.3±2.9b 38.5±3.5b
CD62 L (% of total cells) 48.2±2.8a 46.7±2.5a 35.3±1.1b 39.3±1.2a 31.4±1.4b 15.3±0.5c
CD45RA+(% of total cells) 36.3±1.3a 24.8±1.7b 35.0±1.6a 56.3±0.5a 36.4±3.2b 52.0±1.1c
a

Data presented as cell population percentage mean±s.e.m.; means within a row for a given cell type (splenocytes, mesenteric lymph node (MLN) cells) that do not share a common letter are significantly different (P<0.05). a,b,cMeans within a column that do not share a common letter are significantly different.