. 2009 Apr 28;100(10):1581–1588. doi: 10.1038/sj.bjc.6605051

Table 4. Effects of CPT-11 treatment with our without Cipro on mitogen-stimulated cytokine production by splenocytes and MLN cells.

Mitogen	Cytokine ( × 10⁻⁹ g l⁻¹)	Healthy controls	CPT-11 alone	CPT-11+ Cipro
Spleen
Con A	IL-2	5020±76 (4)^a	2646±234 (9)^b	2398±475 (6)^b
	IL-6	620±19 (4)^a	329±24 (9)^b	535±32 (6)^a
	IL-10	581±38 (4)^a	194±19 (9)^b	181±29 (6)^b
	TNF-α	930±23 (4)^a	257±26 (9)^b	197±20 (5)^b
	IFN-γ	3637±190 (4)^a	1663±157 (9)^b	1185±260 (6)^b

Anti-CD3/28	IL-2	502±37 (4)^a	227±21 (9)^b	199±73 (5)^b
	IL-6	514±140 (4)^a,b	303±45 (7)^b	449±25 (5)^a
	IL-10	129±60 (4)^b	248±31 (9)^a,b	355±60 (5)^a
	TNF-α	210±12 (4)^a	95±14 (9)^b	100±28 (5)^b
	IFN-γ	1972±386 (4)^c	683±128 (9)^a	149±50 (5)^b

LPS	IL-1β	252±24 (4)^a	134±11 (9)^b	196±19 (7)^a
	IL-6	880±82 (4)^a,b	868±87 (9)^b	1247±157 (7)^a
	TNF-α	372±16 (4)^b	437±56 (9)^a,b	577±64 (7)^a
	IFN-γ	1958±160 (4)^a	244±75 (9)^b	127±42 (7)^b

MLN
Con A	IL-2	908±113 (4)^b	2882±364 (6)^a	1381±264 (6)^b
	IL-6	137±10 (4)	129±28 (8)	117±16 (7)
	IL-10	—^*	67±22 (6)	—^*
	TNF-α	68±11 (4)^b	592±83 (8)^a	138±26 (6)^b
	IFN-γ	371±51 (4)^b	2551±506 (7)^a	404±131 (6)^b
Anti-CD3/28	IL-6	23±4 (2)^b	176±19 (8)^a	39±9 (5)^b
	IL-10	94±34 (3)	66±16 (8)	—^*

^*— below detection limit.

^aData are presented as mean±s.e.m. (number of rats), means within a row that do not share a common letter are significantly different (P<0.05). ^a,bMeans within a column that do not share a common letter are significantly different.