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. 2009 Apr 28;100(10):1647–1658. doi: 10.1038/sj.bjc.6605064

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Copyright © 2009 Cancer Research UK

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(A) Gene network of genes related to resistance to IFN-α/5-FU combination therapy. This network with the highest score consisted of 35 molecules in 19 focus molecules (red or green colour) and 16 interconnecting molecules (not coloured). The network included AXIN2, TCF3, RARA, CREBBP and TACSTD1, which are all associated with Wnt/β-catenin signalling. Each value of gene expression correlated directly with the intensity of the node colour. Red: upregulation in non-responders, green: downregulation in non-responders. The ratio of expression of each gene (non-responders/responders) is indicated below each node. (B) The expression levels determined by quantitative RT–PCR analysis correlated significantly with the microarray data. The Pearson correlation coefficient (P-value) for TACSTD1 were 0.668 (P=0.0107) (C) Among non-responders with IFNAR2-positive HCC or IFNAR2-negative HCC, the TACSTD1 expression ratio was higher in several cases than that in responders with IFNAR2-positive HCC. (D) Immunohistochemical staining for Ep-CAM in representative cases. Left panel: the majority of tumour cells showing staining for Ep-CAM on the plasma membrane. Right panel: tumour cells were negative for Ep-CAM. T, tumour lesion; NT, non-tumour lesion. (Magnification, × 200). The colour reproduction of this figure is available on the html full text version of the paper.