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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Proteins. 2009 Mar;74(4):948–960. doi: 10.1002/prot.22203

Table 6.

Binding kinetics and specificity of WFGMT TCR mutant for HLA-A2 with Tax peptide and V7R point mutant of Tax peptide.

peptide ka, ×104 M−1S-1 kd, ×10−3 s−1 KD, nM ΔΔG, kcal/mol Specificity1
Tax 6.32 1.35 21.4 −2.72 ± 0.10 NA
V7R 1.14 2.28 200 −1.40 ± 0.21 9.3
1

Fold change in KD with respect to Tax peptide.