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Mutation of nuclear receptor binding motifs in huntingtin has no effect on transcriptional activation. (A) Immunoprecipitation of Myc-tagged LXR and (B) activity of an LXRE-luciferase reporter expressed in SK-N-SH cells or HEK cells, respectively, in combination with individual Leu to Ala FLAG-huntingtin 1–588 mutants (L211A, L297A, L317A, L326A), a mutant with all five NR binding motifs mutated (quadruple) or a deletion mutant missing the region containing the five motifs (deletion).
