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The antimalaria activity of α-GalCer requires CD1d-positive Vα14 NKT cells. Five CD1-deficient and wild-type (WT) mice on BALB/c and C57BL/6 background (A) and Vα14 NKT-deficient mice (Jα281−/−) or WT mice of these strains (B) were injected i.p. with 1 μg of α-GalCer. Two days later the mice were challenged with P. yoelii sporozoites, and their parasite burden in the liver was assessed as in Fig. 1. The results represent one of two similar experiments expressed as mean values ± SD.
