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The antimalaria activity of α-GalCer is primarily mediated by IFN-γ. Five mice lacking IFN-γ or IFN-γ receptor (A) and mice lacking Fas ligand (gld), perforin (per−/−), or TNF-α (TNF−/−) and their respective WT controls (B) were injected i.p. with 1 μg of α-GalCer. Two days later the mice were challenged with P. yoelii sporozoites, and the parasite burden in the liver was assessed as in Fig. 1. The results represent one of two similar experiments.
