ClustalW alignment of predicted nuclear import (NLS) and export (NES) signals within Dsh proteins from L. variegatus (Weitzel et al., 2004), X. laevis (Sokol et al., 1995), D. melanogaster (Klingensmith et al., 1994), M. musculus (Klingensmith et al., 1996; Sussman et al., 1994; Tsang et al., 1996), and H. sapiens (Greco et al., 1996; Pizzuti et al., 1996a; Pizzuti et al., 1996b). Asterices indicate the NLS residues targeted for mutation.