Figure 4. Cell cycle properties of E2f6 and Bmi1 mutant MEFs.
Mouse embryonic fibroblasts of wild-type (υ), Bmi1 mutant (σ, 5), and E2f6;Bmi1 compound mutant (Σ, λ) mice were assayed for (A) asynchronous proliferation rate, (B) senescence properties, (C) S-phase re-entry following serum withdrawal and re-addition, and (D) p16INK4a and p19ARF expression by RT-PCR from serum-starved cells.