Fig. 1.

Clinical parameters in animals infected with lethal or non-lethal CDV strains. (A) Leukocyte numbers, (B) in vitro proliferation activity of lymphocytes, (C) cell-associated virus titers expressed in 50% log₁₀ tissue culture infectious doses (TCID₅₀) in PBMCs, and (D) neutralizing antibody titers over the first 21 days of the disease. Animals infected with the lethal strains 5804P-eGFP/H (n = 5) or A75eH (n = 6) are represented by circles, those infected with the non-lethal virus 5804P-eGFP/uN (n = 4) and the survivors of infections with chimeric 5804P/A75eH envelope exchange viruses (n = 4) by triangles. Days post-infection are indicated on the X axis, leukocyte number, proliferation activity, cell-associated virus titer, or neutralizing antibody titer on the Y axis. Error bars represent the standard deviation. The narrow dotted lines indicate cut-off values associated with moderate (upper line) and severe (lower line) immunosuppression. The wider dotted line represents the protective threshold of neutralizing antibodies.