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. 2009 May 20;29(20):6526–6534. doi: 10.1523/JNEUROSCI.1429-09.2009

Figure 4.

Figure 4.

Neuronal expression of the cytNmnat1 transgene. Immunofluorescence with the anti-6xHis tag antibody was used to examine the expression of the cytNmnat1 transgene in 6-week-old PrP-cytNmnat1(D) Tg brain (A, B, C, E) and DRG (F). Wild-type brain is shown in D. The highest cytNmnat1 expression was detected in the hippocampus (A). Higher magnification revealed cytNmnat1 expression in the cytosol and neuronal projections in the CA1 pyramidal cells, cortical neurons, and neurons in the dentate gyrus (B, C, E; arrows indicating representative neuronal projections). High levels of cytNmnat1 were also detected in DRG neurons (F). Scale bars: (in D) A, D, 250 μm; (in F) B, C, E, F, 50 μm.