Table 1.

FDA-Approved Indications for H.P. Acthar Gel

Disorder or Disease	Usage or Indication
Adrenal insufficiency	Diagnostic testing of adrenocortical function
Endocrine disorders	Nonsuppurative thyroiditis; hypercalcemia associated with cancer
Nervous system diseases	Acute exacerbations of multiple sclerosis
Rheumatic disorders	For short-term adjunctive therapy in acute episodes or exacerbations in psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis; ankylosing spondylitis; acute and subacute bursitis; acute nonspecific tenosynovitis; acute gouty arthritis; post-traumatic arthritis; synovitis of osteoarthritis; epicondylitis
Collagen diseases	During an exacerbation or as maintenance therapy in selected cases of systemic lupus erythematosus; systemic dermatomyositis (polymyositis); acute rheumatic carditis
Dermatological diseases	Pemphigus; bullous dermatitis herpetiformis; severe erythema multiforme (Stevens–Johnson syndrome); exfoliative dermatitis; severe psoriasis; severe seborrheic dermatitis; mycosis fungoides.
Allergic states	Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: seasonal or perennial allergic rhinitis; bronchial asthma; contact dermatitis; atopic dermatitis; serum sickness.
Ophthalmic diseases	Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as allergic conjunctivitis; keratitis; herpes zoster ophthalmicus; iritis and iridocyclitis; diffuse posterior uveitis and choroiditis; optic neuritis; sympathetic ophthalmia; chorioretinitis; anterior segment inflammation; allergic corneal marginal ulcers
Respiratory diseases	Symptomatic sarcoidosis; Loeffler’s syndrome not manageable by other means; berylliosis; fulminating or disseminated pulmonary tuberculosis when used concurrently with antituberculous chemotherapy; aspiration pneumonitis
Hematological disorders	Acquired (autoimmune) hemolytic anemia; secondary thrombocytopenia in adults; erythroblastopenia (red blood cell anemia); congenital (erythroid) hypoplastic anemia
Neoplastic diseases	For palliative management of leukemias and lymphomas in adults; acute leukemia of childhood
Edematous state	To induce a diuresis or a remission of proteinuria in the nephrotic syndrome without uremia of the idiopathic type or that caused by lupus erythematosus
Gastrointestinal diseases	To tide the patient over during a critical period of the disease in ulcerative colitis; regional enteritis
Miscellaneous	Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy; trichinosis with neurological or myocardial involvement

Data from package insert, Questcor.¹