Phylogenetic trees of HBV strains isolated from 22 blood donors in Papua along with 52 reference strains. (A) Complete genome; (B) pre-C/C gene; (C) S gene. The number in the tree indicates the bootstrap reliability. The lengths of the horizontal bars indicate the number of nucleotide substitutions per site. *, HBV/C5 including P18 in this study cluster in the same branch as HBV/B due to the genetic recombination with HBV/B over the pre-C/C gene. Isolates from the database are indicated with accession numbers, and relevant country names are added to each HBV/B, HBV/C, and HBV/D strain. The nucleotide sequence accession numbers used as references in the phylogenetic trees are as follows: for HBV/B, EF473976, EF473977, M54923, AB033554, D00331, AB219426 through AB219429, AB241116, AB241117, DQ463791, DQ463792, DQ463787 through DQ463794, AY033073, AB073835, D00329, D23678, AF121243, and AF121251; for HBV/C, D23684, M38636, X75656, X75665, AB111946, AB112472, AB241109, AB241113, AB048704, and AB048705; for HBV/D, DQ315779, DQ315780, AB048701, AB048703, AB033559, AY161157, AF151735, AB090269, AB078032, AB078033, AJ132335, and AY902776; for HBV/A, AB014370; for HBV/E, EX75657; for HBV/F, FX75658; for HBV/G, GAF160501; and for HBV/H, HAY090457.