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. 2009 Jun 16;106(26):10829–10834. doi: 10.1073/pnas.0903408106

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Fig. 4. — Ratio images of [Ca²⁺]_ne/er in differentiated NG108–15 cells. Serial images were obtained with ER-cameleon-expressing cells as described in Fig. 3. (A) Control (no KB-R7943): Following Tg application at 50 s leading to depletion of [Ca²⁺]_ne/er, addition of CaCl₂/KCl at 550 sec caused elevation of [Ca²⁺]_ne/er that originated in the perinuclear region (arrowheads at 592.8 s image with *) and then extended to entire NE/ER. This was followed by gradual Tg-induced depletion. (B) Repeat of above experiment with KB-R7943 showed limited uptake of Ca²⁺ in the perinuclear region at 592.9s (*) consistent with incomplete blockade shown in Fig. 3 Aa and Ba; modest rise in [Ca²⁺]_ne/eroccurred briefly to 637.7 s followed by gradual Tg-induced depletion.