Table 1.
Summary of biomarker expression and statistical comparison of biomarker expression in endometrium from healthy control women and patients with endometriosis. GdA = Glycodelin A; OPN = Osteopontin, LPA3 = Lysophosphatidic acid receptor 3, HOXA10
| Biomarker | Histologic secretory phase | Mean HSCORE + SD (n = no. of subjects) | p-value a | |
|---|---|---|---|---|
| Normal | Endometriosis | |||
| GdA | Mid | 2.3 ± 1.1 (n=9) | 2.0 ± 0.7 (n=6) | .761 |
| Late | 3.1 ± 0.4 (n=8) | 2.2 ± 0.9 (n=9) | .049 | |
| OPN | Mid | 3.6 ± 0.3 (n=9) | 3.4 ± 0.4 (n=6) | .127 |
| Late | 3.6 ± 0.2 (n=8) | 2.8 ± 0.4 (n=9) | .0001 | |
| LPA3 | Early | 3.7 ± 0.3 (n=7) | 3.1 ± 0.5 (n=7) | .061 |
| Mid | 3.3 ± 0.4 (n=9) | 2.4 ± 0.4 (n=6) | .006 | |
| Late | 3.5 ± 0.4 (n=8) | 2.6 ± 0.5 (n=9) | .002 | |
| HOXA10 Stroma | Early | 3.1 ± 0.4 (n=7) | 2.8 ± 0.4 (n=7) | .225 |
| Mid | 3.2 ± 0.3 (n=9) | 2.5 ± 0.3 (n=6) | .0006 | |
| Late | 3.2 ± 0.2 (n=8) | 2.4 ± 03 (n=9) | .0001 | |
| HOXA10 Gland | Early | 1.6 ± 0.6 (n=7) | 1.4 ± 0.4 (n=7) | 0.691 |
| Mid | 2.2 ± 0.7 (n=9) | 1.1 ± 0.1 (n=6) | 0.006 | |
| Late | 2.8 ± 0.3 (n=8) | 2.0 ± 0.6 (n=9) | 0.002 | |
a
p-value determined by Wilcoxon test comparing HSCORES values between endometriosis and healthy control subjects and computing exact p-values