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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Glia. 2009 May;57(7):767–776. doi: 10.1002/glia.20804

Fig. 1. Photo-activation of circulating Rose Bengal blocks local blood flow and reduces local evoked potential.

Fig. 1

A) (Top) An image of vasculature labeled with rhodamine-dextran before (left) and 10 min after (right) photothrombosis. Linescan X-t images (lower panels) were performed at the regions identified by the dashed lines in the top panels. Right lower panel shows cessation of movement of blood cells (dark bands, lower left panel) following photothrombosis. B) Time course of evoked potential (EP) changes in the ischemic core stimulated by whisker deflection before and after photothrombosis. Data were recorded from 3 mice with different symbols representing each mouse. The insets in the figure show examples of averaged EPs before (left) and 40 min (right) after ischemia recorded in the core. C) Astrocytes were labeled using SR101 and maximum intensity projection images obtained from 20 Z-scan images (1 µm z-step interval) show the morphology of these glial cells before and following photothrombosis. Images in the bottom panel are enlargements of the boxed regions in the upper panels.