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. Author manuscript; available in PMC: 2010 Jun 15.
Published in final edited form as: Cancer Res. 2009 Jun 2;69(12):5007–5014. doi: 10.1158/0008-5472.CAN-09-0354

Figure 5.

Figure 5

J8H Antibody or genetic inhibition of α6 integrin cleavage inhibited bone metastases. A. SCID mice were injected with untreated PC3B1 cells (PC3B1) or cells containing surface bound J8H (PC3B1 + J8H). B. SCID mice were injected with PC3B1 cells expressing a cleavable α6 integrin (WT) or an uncleavable α6 integrin mutant (RR). In both panels, the entire skeleton of the mouse was inspected for metastases using digital radiographs collected at 3, 4, 5, and 6 weeks after injection. The presence of an osteolytic lesion in any bone was scored as a positive metastasis and all metastatic lesions were progressive (data not shown). The analysis was done without knowledge of the treatment groups. Sample size contained twelve mice per treatment group.