Table 2.
Basal and insulin stimulated metabolite concentrations and metabolic data from the hyperinsulinaemic euglycaemic clamp
| Control diet | HFHC diet | P-value | ||
|---|---|---|---|---|
| Blood glucose (mmol l−1) | Basal | 4.59 ± 0.46 | 5.05 ± 0.40 | <0.001* |
| Ins. stim. | 5.11 ± 0.31 | 5.17 ± 0.30 | 0.44 | |
| Serum insulin (pmol l−1) | Basal | 31.4 ± 14.2 | 43.4 ± 29.2 | 0.07 |
| Ins. stim. | 870 ± 232 | 867 ± 181 | 0.97 | |
| Serum C-peptide (pmol l−1) | Basal | 408 ± 146 | 529 ± 260 | 0.05* |
| Ins. stim. | 406 ± 279 | 453 ± 195 | 0.26 | |
| GOX (mg kg−1 FFM min−1) | Basal | 2.41 ± 0.83 | 2.53 ± 0.76 | 0.60 |
| Ins. stim. | 5.18 ± 0.80 | 5.03 ± 0.90 | 0.59 | |
| FOX (mg kg−1 FFM min−1) | Basal | 0.98 ± 0.39 | 0.98 ± 0.34 | 0.89 |
| Ins. stim. | 0.02 ± 0.25 | 0.16 ± 0.30 | 0.08 | |
| NOGM (mg kg−1 FFM min−1) | Ins. stim. | 7.54 ± 2.82 | 7.18 ± 2.73 | 0.61 |
| Rd (mg kg−1 FFM min−1) | Basal | 2.29 ± 0.57 | 2.97 ± 1.12 | 0.01* |
| Ins. stim. | 12.23 ± 2.38 | 11.78 ± 2.50 | 0.41 | |
| GF (mg kg−1 FFM min−1) | Basal | 1.64 ± 1.96 | 2.16 ± 4.52 | 0.60 |
| Ins. stim. | 4.62 ± 2.17 | 3.47 ± 2.55 | 0.05* | |
| Non-ox.GF (mg kg−1 FFM min−1) | Ins. stim. | −0.07 ± 2.47 | −0.95 ± 2.68 | 0.15 |
| EGS (mg kg−1 FFM min−1) | Basal | 0.87 ± 1.83 | 1.98 ± 4.14 | 0.23 |
| Ins. stim. | 7.60 ± 2.77 | 8.38 ± 3.10 | 0.35 |
Data are means ±s.d.*Significant differences between control and HFHC diet.