Table 3.

Results of the IVGTT before and after the HFHC diet

	Control diet	HFHC diet	P-value
First phase insulin response (FPIR)	1894 ± 1431	2604 ± 1793	<0.001*
DI of insulin secretion (peripheral ins. action)	0.29 ± 0.19	0.35 ± 0.19	0.04*
DI of insulin secretion (hepatic ins. action)	0.38 ± 0.64	0.25 ± 0.21	0.36

Data are means ±s.d. The first phase insulin response (0–10 min) is used as a measure of insulin secretion. The disposition indices (DI) of insulin secretion are calculated to correct insulin secretion for the degree of in vivo peripheral and hepatic insulin action respectively. n= 26.

^*Significant differences between control and HFHC diet.