Table 2.

Results for Aggressive and Early Onset PRCA subset analyses.

	Aggressive PRCA*		Early Onset PRCA†
SNP	Per allele OR (95% CI) ‡	Trend p-value§	Per allele OR (95% CI)	Trend p-value
rs2660753	1.17 (0.76–1.80)	0.8288	1.33 (0.78–2.28)	0.3138
rs9364554	1.02 (0.74–1.39)	0.7546	0.96 (0.63–1.46)	0.8349
rs6465657	1.23 (0.92–1.65)	0.5661	1.24 (0.84–1.81)	0.2639
rs10993994	1.42 (1.05–1.90)	0.0064	2.20 (1.48–3.27)	<0.0001
rs7931342	0.92 (0.68–1.23)	0.4594	0.89 (0.60–1.32)	0.5792
rs2735839	1.22 (0.81–1.82)	0.5033	1.04 (0.62–1.74)	0.8976
rs5945619	1.55 (0.97–2.49)	0.0697	1.46 (0.85–2.49)	0.1779

^*Aggressive PRCA was defined as: 1) regional lymph nodes or distant metastasis; 2) poorly differentiated or undifferentiated grade (Gleason sum 8–10); or 3) death due to metastatic prostate cancer, confirmed by death certificate. Combined total for familial, aggressive PRCA was 105;

^†Early onset was defined as diagnosis of disease at ≤65 years of age. Combined total for familial, early onset PRCA was 73;

^‡Cochran-Mantel-Haenszel meta OR across both case-control sets;

^§Cochran-Mantel-Haenszel meta trend test (except for the X chromosome SNP where an allele test has been performed).