Figure 3. Phenotypic characterization of Apc +/1572T mice: mammary adenocarcinomas are composed by mixed differentiation lineages with heterogeneous patterns of β-catenin intracellular accumulation and subcellular localization.
Survival curves of (A) female and (B) male Apc +/1572T mice, respectively. The black, green and red lines are representative of mice in the 129Ola, F1 B6x129Ola, and B6 respectively. Please note that in these graphs, age of death represents the moment at which, due to the presence of signs of discomfort or because the tumor size exceeded 2 cm3, mice had to be euthanized according to institutional and national regulations. (C) Macroscopic image of the appearance of the mammary adenocarcinomas characteristic of the Apc1572T model. (D) Examples of global digital microscopy scans of two mammary adenocarcinomas from Apc +/1572T mice illustrative of the multi-lineage nature of these lesions.