Table 1.
Attenuation of the development of physical dependence to three BZD receptor agonists by co-treatment with the BZD receptor antagonist flumazenil as manifested by an attenuated decrease in pLMV. Planarians were pretreated for 60 min and tested for 5 min under the conditions indicated. N = 10 planarians per group.
| Pretreatment | Test | pLMV | Pa |
|---|---|---|---|
| Midazolam | Water | 26.4 ± 1.5 | — |
| Midazolam + Flumazenil | Water | 37.0 ± 1.5 | < 0.001 |
| Clorazepate | Water | 27.5 ± 1.6 | — |
| Clorazepate + Flumazenil | Water | 44.7 ± 1.5 | < 0.001 |
| Zolpidem | Water | 20.4 ± 1.7 | — |
| Zolpidem + Flumazenil | Water | 44.3 ± 1.6 | < 0.001 |
a
Comparison of agonist to agonist + antagonist