Table 2. Descriptive statistics for the amount of DNA damage before and after PDT and ranibizumab treatment.
| Type of treatment |
Photodynamic therapy (PDT) |
Ranibizumab |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Prior to treatment | 30 min | 45 min | 60 min | 24 h | Prior to treatment | 30 min | 45 min | 60 min | 24 h | |
| Mean |
0.22 |
0.53 |
0.33 |
0.23 |
0.20 |
0.30 |
0.22 |
0.14 |
0.13 |
0.15 |
| Median |
0.19 |
0.46 |
0.28 |
0.21 |
0.19 |
0.24 |
0.19 |
0.14 |
0.16 |
0.16 |
| StdDev |
0.11 |
0.24 |
0.23 |
0.12 |
0.11 |
0.18 |
0.16 |
0.08 |
0.06 |
0.08 |
| Minimum |
0.14 |
0.36 |
0.10 |
0.13 |
0.13 |
0.12 |
0.08 |
0.06 |
0.06 |
0.06 |
| Maximum |
0.44 |
1.00 |
0.74 |
0.46 |
0.45 |
0.64 |
0.42 |
0.21 |
0.20 |
0.21 |
| N |
6 |
6 |
6 |
6 |
6 |
6 |
6 |
6 |
6 |
6 |
| p value | p=0.004* | ns | ns | ns | ns | ns | ns | ns | ns | |
PDT induced a transient increase in the amount of single stranded DNA damage in the circulating leukocytes from 0.22 AU (before treatment) to 0.53 AU (30 min after treatment).The asterisk indicates a significant result was only obtained after 30 min.