Table 1.

Anti-HIV data of compounds 3a–c in acutely infected H9 lymphocytes

Compound	IC50 (μM)a	EC50 (μM)b	TIc
3a	57.2	0.068	841
3b	54.4	0.083	659
3cd	>39.4	<0.39	>100
DCKe	>16.1	0.049	>328
4-Me DCKe	>38.9	0.0059	>6,600
AZT	500	0.0137	36,520

^aConcentration that inhibits uninfected H9 cell growth by 50%.

^bConcentration that inhibits viral replication by 50%.

^cTI = therapeutic index IC₅₀/EC₅₀.

^dMore precise data could not be determined due to solubility problems.

^eThe data for DCK and 4-methyl DCK were cited from Ref. 8. EC₅₀ and TI values for DCK and 4-methyl DCK were 2.56 × 10⁻⁴ μM, 1.83 × 10⁻⁶ μM, and 1.37 × 10⁵, 6.89 × 10⁷, respectively, in previous screenings, using a different methodology, and publications.¹