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Schema to correct mutant p53 transcripts with targeted trans splicing. Mutant messages can be recognized by a ribozyme at any uridine upstream of the mutation (marked by Xm) by base pairing to the sequence through its IGS. The ribozyme then removes the mutation-containing sequence and replaces it with a 3′ exon that encodes the correct sequence for the wt transcript. The extended IGS and P10 interactions are shown.
