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Summary of mean (% coefficient of variation) dexrazoxane pharmacokinetic parameters at a dosage ratio of 10:1 of dexrazoxane: doxorubin
| Dose doxorubicin (mg/m2) | 50 | 60 |
| Dose dexrazoxane (mg/m2) | 500 | 600 |
| Number of subjects | 10 | 5 |
| Elimination half-life (h) | 2.5 (16) | 2.1 (29) |
| Plasma clearance (L/h/m2) | 7.88 (18) | 6.25 (31) |
| Renal clearance (L/h/m2) | 3.35 (36) | – |
| Volume of distribution (L/m2)a | 22.4 (22) | 22.0 (55) |
Steady stage volume of distribution.
