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. 2009 Mar 26;5:21–34.

Table 2.

Metabolism of 5-HT₃ antagonists

Drug	Primary pathway	Secondary pathway
Dolasetron^a	CYP2D6	CYP3A
Granisetron	CYP3A	CYP3A4
Ondansetron	CYP3A4	CYP1A2 CYP2D6 CYP2E1
Ramosetron	CYP1A2	CYP2D6 CYP141
Tropisetron	CYP2D6	CYP3A4 CYP2E1
Palonosetron	CYP2D6	CYP3A4 CYP1A2

^{^a}

Values are those for the active metabolite hydrolosetron.